Pregnancy Associated Breast Cancer di Rumah Sakit Onkologi Surabaya 2006 2014

JACOBUS OCTOVIANUS, SAVITRI KUNTARI, ARIO DJATMIKO

Abstract


ABSTRACTPregnancy associated breast cancer (PABC) is the most common malignancy in gestation. Due to its high aggressiveness, PABC needs a specific management right from diagnosis process to therapy. The objective of this study is to find out the PABC profile in Rumah Sakit Onkologi Surabaya from 2006-2014. A descriptive study using PABC Medical Record datafrom 2006 until 2014. There were 21 PABC patients of whom 11 was diagnosed on 31-40 years old (52.38%); 16 PABC patients with multiparity (76.19%); 14 (66.67%) PABC diagnosed at 1 year post partum; 18 USG and 6 Mammography examinations, both revealed 100% sensitivity in diagnosing PABC; 14 patients (66,67%) in stadium III-IV; 9 patients (42,86%) with T4 tumor size; 9 patients (42,86%) with axillary lymphnode metastasis ; 4 patients (19,05%) with distant metastasis; 10 patients (47,62%) with Invasive Ductal Carcinoma (IDC); 14 patients (66,67%) grade III; and 8 patients (38,10%) with angioinvasion. Positive ER/PR in 11 patients (52,38%) and positive Her-2 in 10 patients (47,62%). PABC prognosis were: 8 patients (38,10%) in good condition, while 5 patients (23.81%) had distant metastasis, and 4 patients (19,05%) passed away. Twenty one babies born healthy (100%). The aggressiveness of PABC can be seen from the percentage of patients in advanced stage and has worse prognosis.Keywords: breast cancer, pregnancyABSTRAKPregnancy Associated Breast Cancer (PABC) merupakan keganasan yang paling sering ditemukan pada kehamilan. Karena agresivitas yang tinggi, PABC memerlukan penanganan yang khusus, baik saat penegakan diagnosis maupun tindakan terapi. Penelitian ini bertujuan mengetahui profil PABC di Rumah Sakit Onkologi Surabaya sejak 2006-2014. Studi deskriptif ini menggunakan data rekam medis pasien PABC sejak 2006 hingga 2014. Hasil penelitian menunjukkan kasus PABC sebanyak 21 pasien. Jumlah PABC tertinggi ditemukan pada usia 31-40 tahun, yaitu 11 pasien (52,38%); 16 pasien (76,19%) PABC didapatkan pada multiparitas; 14 pasien (66,67%) pada 1 tahun post-partum. Pada 18 pemeriksaan USG dan 6 pemeriksaan mammografi memiliki tingkat sensitivitas 100%; 14 pasien (66,67%) pada stadium III-IV; 9 pasien (42,86%) tumor T4; 12 pasien (57,14%) metastasis ke kelenjar getah bening; 4 pasien (19,05%) metastasis jauh; 10 pasien (47,62%) Invasive Ductal Carcinoma (IDC); 14 pasien (66,67%) pada grade III; 8 pasien (38,10%) memiliki angioinvasion; 11 pasien (52,38%) memiliki ER/PR positif; dan 10 pasien (47,62%) memiliki Her-2 positif. Pada follow up didapatkan 8 pasien (38,10%) berada dalam kondisi baik, 5 pasien mengalami metastasis jauh (23,81%), dan 4 pasien meninggal (19,05%). Dua puluh satu bayi terlahir sehat (100%). Kesimpulannya, agresivitas PABC dapat dilihat dari besarnya persentase pasien yang datang pada stadium lanjut dan prognosis yang buruk.Kata Kunci: kanker payudara, kehamilan

Keywords


breast cancer; pregnancy

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DOI: 10.33371/ijoc.v9i2.377

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References


Roman R, Mir O, Uzan C, Delagoge S, et al.2008. Management

of breast cancer during pregnancy. Recommandations du

groupe francais detude des cancers gynecologique et de la

grossesse.

Middleton LP, Amin M, Gwyn K, Theriault R, Sahin A. Breast

carcinoma in pregnant women: assessment of clinicopathologic

and immunohistochemical features. Cancer 2003; 98:105560.

IshidaT,YokoeT, KasumiF,etal. Clinicopathologiccharacteristi

csand prognosis of breast cancer patients associated with

pregnancy and lactation: analysisofcase-controlstudyinJapan.

Jpn J Cancer Res 1992; 83: 11439.

Doger E, Caliskan E, Mallman P. Pregnancy associated breast

cancer and pregnancy after breast cancer treatment. J Turk

Ger Gynecol Assoc 2011; 12; 4: 24755.

Lambe M, Hsieh C, Trichopoulos D, Ekbom A, Pavia M,

Adami HO. Transient increase in the risk of breast cancer

after giving birth. N Engl J Med 1994;331:59.

Kalache A, Maguire A, Thompson SG. Age at last full-term

pregnancy and risk of breast cancer. The Lancet 1993 Jan

;341 : 33-6.

Lyons TR, Schedin PJ, Borges V. Pregnancy and Breast Cancer

: when They Collide. J Mammary Gland Biol Neoplasia 2009;

: 87-98.

Van Den Rul, Han S.N, Calsteren K.V, Neven P, Amant F.

Postpartum breast cancer behaves differently. F, V & V in

ObGyn, 2011; 3 (3): 183-8.

Joseph M, Montse C, Sofia T, et al. Radiologic Evaluation of

Breast Disorders Related to Pregnancy and Lactation.

Radiographic2007 ; 27: 101-24.

Robbins J, Jeffries D, Robidoux M, Helvie M. Accuracy of

Diagnostic Mammography and Breast Ultrasound During

Pregnancy and Lactation. AJR 2011; 196:716-22.

Ayyappan AP, Kulkarni S, Crystal. Pregnancy associated

breast cancer : spectrum of imaging appereances. The British

Journal of Radiology2010 ; 83: 529-34.

Partridge A, Schapira L. Pregnancy and Breast Cancer.

Oncology (Williston Park) 2005; 19; 6:693-7.

Loibl S, von Minckwitz G, Gwyn K, Ellis P, Blohmer JU,

Schlegelberger B et al : Breast carcinoma during pregnancy.

International recommendations from an expert meeting.

Cancer 2006; 106 (2) : 237-46.

Litton JK, Theriault R. Breast Cancer and Pregnancy: Current

Concepts in Diagnosis and Treatment. The Oncologist

;15:123847.

Navrozoglou. Breast cancer during pregnancy: A mini-review.

The Journal of Cancer Surgery2008 ; 34 : 837-43.

Deckers S, Amant F. Breast cancer in pregnancy: a literature

review. F,V& V In Obgyn 2009; 1; 2: 130-41.

Toesca A, Gentilini O, Peccatori F, Azim H Jr, Amant

F. Locoregional treatment of breast cancer during pregnancy.

Gynecol Surg 2014; 11(4): 27984.

Amant F, Deckers S, Van Calsteren K, Loibl S, Halaska

M, Brepoels L, et al. Breast cancer in pregnancy: recommendations

of an international consensus meeting. Eur J Cancer 2010

Dec;46; (18): 3158-68.

Rouzier R et al. Pregnancy-associated breast cancer is as

chemosensitive as non-pregnancy-associated breast cancer

in the neoadjuvant setting. Annals of Oncology 2011; 22:

7.


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