Correlation between Age and Body Mass Index (BMI) with Histopathological Features of Breast Cancer Patients in RSUP Haji Adam Malik Medan
Background: Breast cancer is influenced by various risk factors, including age and obesity. Older women who are overweighted and obese have a higher risk of developing breast cancer. This study aims to find the correlation between age and body mass index (BMI) with histopathological features of breast cancer patients in RSUP Haji Adam Malik Medan.
Methods: This research is an analytical study using a cross-sectional design with 103 samples obtained from medical record data by random sampling. The data obtained were then adjusted to the research criteria and grouped based on predetermined variables.
Results: The majority of the age group was 41-50 years (36.9%), obesity BMI (40.8%), histopathological subtype of invasive carcinoma of no special type (NST) (85.4%), and grade II (46.6%). Kruskal-Wallis test result between histopathological subtypes and breast cancer grading based on age, respectively, obtained p=0.503, r=.325; (α>0.05), and p=0.207, r=0.393; (α>0.05), while based on BMI obtained p=0.017, r=0.021; (α<0.05), and p=0.018, r=0.018; (α<0.05). The OR value (95% CI) obtained on overweight-obese BMI with invasive carcinoma NST subtype was 7.63 (7.27–14.90) and other subtypes were 2.40 (1.14–13.75), and for grades II and III, they were respectively 3.57 (1.32–8.09) and 3.27 (1.17–9.91).
Conclusions: There was a correlation between BMI with histopathological subtypes and breast cancer grading, but the correlation tended to be weak. Whereas, with age, there was no correlation. BMI overweight-obese were more likely to have invasive carcinoma NST subtype and higher-grade of breast cancer.
Kementerian Kesehatan RI. InfoDatin, Pusat Data dan Informasi Kementerian Kesehatan RI Bulan Peduli Kanker Payudara 2016 [Internet]. 2016 [cited 2019 Apr 7]. Available from: http://www.depkes.go.id/article/view/17010500002/infodatin-kanker payudara.html
World Health Organization. Breast Cancer : Cancer [Internet]. 2019 [cited 2019 Apr 7]. Available from: https://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/
International Agency for Research on Cancer. Indonesia - Global Cancer Observatory [Internet]. 2019 [cited 2019 Apr 7]. Available from: http://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
Centers for Disease Control and Prevention. What Are the Risk Factors for Breast Cancer? [Internet]. 2018 [cited 2019 Apr 14]. Available from: https://www.cdc.gov/cancer/breast/basic_info/risk_factors.htm
World Health Organization. Obesity [Internet]. 2019 [cited 2019 Apr 14]. Available from: https://www.who.int/topics/obesity/en/
Centers of disease control. Body mass index: Considerations for practitioners. Cdc [Internet]. 2011;4. Available from: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Body+Mass+Index+:+Considerations+for+Practitioners#3%5Cnhttp://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Body+mass+index:+Considerations+for+practitioners%233
Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, Van de VMJ (Eds). WHO Classifications of Tumours of the Breast. Lyon: IARC; 2012.
Lu Z, Chen J. Introduction of WHO classification of tumours of female reproductive organs, fourth edition. Chinese J Pathol. 2014;43(10):649–50.
Rahmatya A, Khambri D, Mulyani H. Hubungan usia dengan gambaran klinikopatologi kanker payudara di Bagian Bedah RSUP Dr. M. Djamil Padang. J Kesehat Andalas. 2015;4(2):478-84.
Hassan O. What is the Nottingham combined histologic grade (modified Scarff-Bloom-Richardson grade) system for breast tumors? Medscape [Internet]. 2019 [cited 2020 Mar 7]. Available from: https://www.medscape.com/answers/1668113-181367/what-is-the-nottingham-combined-histologic-grade-modified-scarff-bloom-richardson-grade-system-for-breast-tumors
Prawirohardjo AN, Soewoto W, Alfianto U. Hubungan index massa tubuh dengan grading pada kanker payudara. Biomedika. 2018;10(1):41–5.
Partridge AH, Hughes ME, Warner ET, et al. Subtype-dependent relationship between young age at diagnosis and breast cancer survival. J Clin Oncol. 2016;34(27):3308–14.
Abubakar M, Chang-Claude J, Ali HR, et al. Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation. Int J Cancer. 2018;143(4):746–57.
Laudisio D, Muscogiuri G, Barrea L, et al. Obesity and breast cancer in premenopausal women: Current evidence and future perspectives. Eur J Obstet Gynecol Reprod Biol. 2018;230:217–21.
Blair CK, Wiggins CL, Nibbe AM, et al. Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics. npj Breast Cancer. 2019;5(1):1–7.
Picon-Ruiz M, Morata-Tarifa C, Valle-Goffin JJ, et al. Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention. CA Cancer J Clin. 2017;67(5):378–97.
Sastroasmoro, Sudigdo Ismael S. Dasar – Dasar Metodologi Penelitian Klinis. Fourth. Jakarta: Sagung Seto; 2017.
Dabbs D. Breast Pathology 2nd Edition [Internet]. Second. Canada: Elsevier Inc; 2017 [cited 2019 Apr 7]. Available from: https://www.elsevier.com/books/breast-pathology/unknown/978-0-323-46236-5
Suryani R, Subandriyo HD, Yanti DE. Faktor resiko yang berhubungan dengan kejadian kanker payudara di Rumah Sakit Umum Daerah dr. H.Abdoel Moeloek Provinsi Lampung. J Kesehat. 2016;7(1):73.
Hillers LE, D’Amato J V, Chamberlin T, et al. Obesity-activated adipose-derived stromal cells promote breast cancer growth and invasion. Neoplasia. 2018;20(11):1161–74.
Firasi AA, Yudhanto E. Hubungan usia terhadap derajat diferensiasi kanker payudara pada wanita. JKD. 2016;5(4):327–36.
Kawai M, Minami Y, Nishino Y, et al. Body mass index and survival after breast cancer diagnosis in japanese women. BMC Cancer. 2012;12:149.
Berclaz G, Li S, Price K. Body mass index as a prognostic feature in operable breast cancer: The international breast cancer study group experience. Ann Oncol. 2004;15:875–84.
Sun LM, Zhu YM, Qian QM, Tang LM. Body mass index and prognosis of breast cancer - an analysis by menstruation status when breast cancer diagnosis. Medicine. 2018;97(26):1–2.
Firdaus V, Asri A, Khambri D. Hubungan grading histopatologi dan infiltrasi limfovaskular dengan subtipe molekuler pada kanker payudara invasif di Bagian Bedah RSUP. Dr. M. Djamil Padang. J Kesehat. 2016;5(1):165–72.
Gershuni V, Li YR, Williams AD, et al. Breast cancer subtype distribution is different in normal weight, overweight, and obese women. Breast Cancer Res Treat. 2017;163(2):375–81.
Irena R. Hubungan obesitas dengan kejadian kanker payudara di RSUD Bangkinang. PREPOTIF Jurnal Kesehatan Masyarakat. 2018;2(1):1-8.
Article MetricsAbstract view : 175 times
PDF - 100 times
- There are currently no refbacks.
Copyright (c) 2021 Indonesian Journal of Cancer
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.