A Case Report of Double Primer Cancer: Malignant Phyllodes Tumor and Invasive Ductal Carcinoma
Introduction: Multiple primaries have been reported in patients with breast cancer in the range of 4.1% to 16.4%. This report followed the standard Surgical Case Report (SCARE) and discussed two histologically distinct breast cancer malignancies. This paper also explored the risk factor, pathogenesis, treatment, and prognosis of multiple primary malignancies in the same organs, especially in the breasts.
Case Presentation: The patient was a 45-year-old woman with a lump in the left and right breasts for five years. The patient claimed that the lump was enlarged and painless. The tumor size of the left breast was 3 x 2 x 3 cm, the right breast was 4 x 2 x 4 cm, and the patient had no enlargement of lymph nodes. The patient underwent a biopsy examination of the left breast showing invasive ductal carcinoma NST (No Special Type) 3rd grade with LV1 (+). The biopsy examination of the right breast showed malignant phyllodes tumor. Thus, the patient must undergo chemotherapy and mastectomy as definitive therapy. The patient has already completed the treatment and is currently under evaluation.
Conclusion: This report looked for the rare case of double primary malignancies in the breasts. It highlighted double primary cancers starting to increase these days but in a particular way because it happens in the same organ, the breasts. However, medical literature rarely presented a synchronous malignancy case, prompting the publishing of this case. With improved cancer treatment and more prolonged survival, the number of patients with double cancers is increasing.
Bagri PK, Singh D, Singhal MK, et al. Double primary malignancies: A clinical & pathological analysis report from a regional cancer institute in India. Iran J cancer Prev. 2014;7(2):66.
De Luca A, Frusone F, Vergine M, et al. Breast cancer and multiple primary malignant tumors: case report and review of the literature. In Vivo (Brooklyn). 2019;33(4):1313–24.
Vogt A, Schmid S, Heinimann K, et al. Multiple primary tumours: challenges and approaches, a review. ESMO open. 2017;2(2):e000172.
Stracci F, Fabrizi V, D’Alò D, et al. Risk of multiple primary cancers following melanoma and non‐melanoma skin cancer. J Eur Acad Dermatology Venereol. 2012;26(11):1384–8.
Da Silva L, Lakhani SR. Pathology of hereditary breast cancer. Mod Pathol. 2010;23(2):S46–51.
Acharya P, Ramakrishna A, Kanchan T, Magazine R. Dual primary malignancy: A rare organ combination. Case Rep Pulmonol. 2014;2014.
Dalal AK, Gupta A, Singal R, et al. Bilateral breast carcinoma- a rare case report. J Med Life. 2011;4(1):94–6.
de Aquino RGF, Vasques PHD, Cavalcante DIM, et al. Carcinoma ductal invasor: relação de características anatomopatológicas com a presença de metástases axilares em 220 casos. Rev Col Bras Cir. 2017;44:163–70.
Watkins EJ. Overview of breast cancer. JAAPA. 2019 Oct;32(10):13–7.
Shiovitz S, Korde LA. Genetics of breast cancer: a topic in evolution. Ann Oncol Off J Eur Soc Med Oncol. 2015 Jul;26(7):1291–9.
Hill LRS, Duis J, Kulungowski AM, et al. A challenging diagnosis: PTEN hamartoma tumor syndrome presenting as isolated soft-tissue vascular anomalies. J Vasc Anomalies. 2021;2(2):e011.
Cummings K, Watkins A, Jones C, et al. Behavioural and psychological features of PTEN mutations: a systematic review of the literature and meta-analysis of the prevalence of autism spectrum disorder characteristics. J Neurodev Disord. 2022;14(1):1–27.
Plamper M, Gohlke B, Woelfle J. PTEN hamartoma tumor syndrome in childhood and adolescence—a comprehensive review and presentation of the German pediatric guideline. Mol Cell Pediatr. 2022;9(1):1–12.
Pena-Couso L, Ercibengoa M, Mercadillo F, et al. Considerations on diagnosis and surveillance measures of PTEN hamartoma tumor syndrome: clinical and genetic study in a series of Spanish patients. Orphanet J Rare Dis. 2022;17(1):1–11.
Gall TMH, Frampton AE. Gene of the month: E-cadherin (CDH1). J Clin Pathol. 2013 Nov;66(11):928–32.
Vasca EM, Lile I, Luce A, et al. Immunohistochemical Examination of E-Cadherin in the Head and Neck Squamocellular Carcinomas. Int J Otolaryngol Head Neck Surg. 2014;3(06):330.
Kaszak I, Witkowska-Piłaszewicz O, Niewiadomska Z, et al. Role of Cadherins in Cancer-A Review. Int J Mol Sci. 2020 Oct;21(20).
Soerjomataram I, Coebergh JW. Epidemiology of multiple primary cancers. Methods Mol Biol. 2009;471:85–105.
Amir RA, Rabah RS, Sheikh SS. Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature. Case Rep Oncol Med. 2018 Jun 27;2018:6491675.
Limaiem F, Kashyap S. Phyllodes Tumor Of The Breast. 2022 Sep 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–.
Article MetricsAbstract view : 111 times
PDF - 75 times
- There are currently no refbacks.
Copyright (c) 2022 Indonesian Journal of Cancer