Extensive Vulvectomy and Reconstructive Flaps for Advanced Vulvar Cancer in Young Woman: Case Reports
Abstract
Introduction: : Vulvar cancer is a rare disease accounting for approximately 5% of female genital tract tumors worldwide. It is a squamous cell cancer that mostly affects older women over the age of 65. In the existing body of literature, no instances of vulvar cancer have been documented in the form of case reports. Therefore, this study aimed to report the challenges and outcomes of vulvectomy with reconstructive flap in vulvar cancer survivors in a 39-year-old woman.
Case Presentation: A 39-year-old woman with a palpable lump around the vulva was present and being examined. The anatomic pathology report (APR) features suggested poorly differentiated malignant tumors. A neoadjuvant chemotherapy was then administered to the patient aimed at shrinking the size of the tumor. However, there was no effective response to the chemotherapy, which resulted in a progressive tumor. Extensive vulvectomy and reconstructive flap were carried out to support quality of life, and the outcomes were reported, including flap, survival, complications, and mortality. These outcomes were evaluated between November 2021 and March 2023. No total flap loss was observed, and neither was there any donor site morbidity or mortality during the process.
Conclusions: This study showed that vulvar cancer was a rare condition at a young age. Advanced vulvar cancer was found in the patients and extensive vulvectomy surgery was carried out followed by a pedicled ALT flap. This option was currently the best for immediate reconstruction due to the preservation of sensibility and tissue availability in the donor areas. The result showed no wound dehiscence, marginal necrosis, or surgical site infection. After 15 months of follow-up, the flap was observed to have good vascularization. The association of the Gynecologist with the Plastic Surgeon offered palliative care to improve the quality of life of the patient and provide good postoperative results.
Keywords
DOI: 10.33371/ijoc.v17i4.1062
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References
Franco D, Almeida G, Arnaut M Jr, et al. Analysis of the use of fasciocutaneous flaps for immediate vulvar reconstruction. Rev Col Bras Cir. 2012;39(1):54-9.
Capozzi VA, Monfardini L, Sozzi G, et al.
Subcutaneous vulvar flap viability evaluation with near-infrared probe and indocyanine green for vulvar cancer reconstructive surgery: A Feasible Technique. Front Surg. 2021;8:721770.
Kumar N, Ray MD, Sharma DN, et al. Vulvar cancer: surgical management and survival trends in a low resource setting. J Egypt Natl Canc Inst. 2020;32:4.
Miljanović-Špika I, Madunić MD, Topolovec Z, et al. Prognostic factors for vulvar cancer. Acta Clin Croat. 2021;60(1):25-32.
Schnack TH, Froeding LP, Kristensen E, et al. Preoperative predictors of inguinal lymph node metastases in vulvar cancer - A nationwide study. Gynecol Oncol. 2022;165(3):420-7.
Roh S, Miyamoto S, Kitamura Y, et al. Secondary vulvar reconstruction using bilateral gluteal fold flaps after radical vulvectomy with direct closure. Plast Reconstr Surg Glob Open. 2021;9(4):e3550.
Capozzi VA, Ceni V, Sozzi G, et al. Endoscopic near infrared and indocyanine green to verify the viability of the subcutaneous flap for vulvar cancer. Gynecol Oncol. 2019;154(3):653-4.
Hand LC, Maas TM, Baka N, et al. Utilizing V-Y fasciocutaneous advancement flaps for vulvar reconstruction. Gynecol Oncol Rep. 2018;26:24-8.
Zhang J, Zhang J, Ge J, et al. Experience with flap repair after vulvar carcinoma resection: a retrospective observational study of 26 cases. Transl Cancer Res. 2022;11(6):1740-9.
Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009;105(2):103-4.
Perrone AM, Ferioli M, Argnani L, et al. Quality of life with vulvar carcinoma treated with palliative electrochemotherapy: The ELECHTRA (ELEctroCHemoTherapy vulvaR cAncer) Study. Cancers (Basel). 2021;13(7):1622.
de Melo Ferreira AP, de Figueiredo EM, Lima RA, et al. Quality of life in women with vulvar cancer submitted to surgical treatment: a comparative study. Eur J Obstet Gynecol Reprod Biol. 2012;165(1):91-5.
Muallem MZ, Sehouli J, Miranda A, et al. Reconstructive surgery versus primary closure following vulvar cancer excision: A wide single-center experience. cancers (Basel). 2022;14(7):1695.
Olawaiye, AB, Cuello, et al. Cancer of the vulva: 2021 update. Int J Gynecol Obstet. 2021; 155(1): 7–18.
Tagliaferri L, Lancellotta V, Casà C, et al. The radiotherapy role in the multidisciplinary management of locally advanced vulvar cancer: A multidisciplinary vulcan team review. Cancers (Basel). 2021;13(22):5747.
Specchia ML, Frisicale EM, Carini E, et al. The impact of tumor board on cancer care: evidence from an umbrella review. BMC Health Serv Res. 2020;20(73).
Landuyt KV. The anterolateral thigh flap for lower extremity reconstruction. Semin Plast Surg. 2006;20(2):127–32.
Salom EM, Penalver M. Recurrent vulvar cancer. Curr Treat Options Oncol. 2002;3(2):143-53.
Vorbeck CS, Vogelius IR, Banner-Voigt MLVC, et al. Survival and failure types after radiation therapy of vulvar cancer. Clin Transl Radiat Oncol. 2017;5:20-7.
Landoni F, Proserpio M, Maneo A, et al. Repair of the perineal defect after radical vulvar surgery: direct closure versus skin flaps reconstruction. A retrospective comparative study. Aust N Z J Obstet Gynaecol. 1995 Aug;35(3):300-4.
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