Overall Survival for Stage III Breast Cancer Patients at DR. Mohammad Hoesin General Hospital Palembang and the Influencing Factors
Background: There is still a limited number of studies related to overall survival in breast cancer patients in Indonesia. This study determines the overall survival and the factor which can affect the survival of stage III breast cancer patients.
Methods: This study was a retrospective study. Patients first diagnosed with stage III breast cancer from January 1 to August 31, 2018, at DR. Mohammad Hoesin General Hospital Palembang had been studied. The primary outcome of this study was overall survival. The sociodemographic, clinicopathology, and treatment factors were analyzed to identify the independent variables associated with overall survival using Kaplan-Meier and Cox proportional hazard regression.
Results: In this study, 78 samples were included. The 3-year overall survival for stage III breast cancer was 71%. In the bivariate analysis, several factors including older age (> 40) (HR = 2.795, 95% CI 1.223–6.387), higher stages for IIIB (HR = 7.155, 95% CI 0.960–53.334), and IIIC (HR = (HR = 33.450, 95% CI 3.013-371.354), history of not undergoing surgical intervention (HR = 3.999, 95% CI 1.684–9.495), and adjuvant chemotherapy (HR = 2.768, 95% CI 1.211–6.327) have been associated significantly to lower overall survival. Multivariate analysis showed IIIC breast cancer stage as an independent factor and had a significantly increased probability of mortality (HR = 14.677, 95% CI 1.268–169.948).
Conclusions: The stage at diagnosis was the only significant predictor for the survival outcome, indicating that early diagnosis may need more attention.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249.
The Global Cancer Observatory. Cancer Statistic Indonesia 2020. Globocan. 2021 March; 1-2.
Sun YS, Zhao Z, Yang ZN, et al. Risk Factors and Preventions of Breast Cancer. Int J Biol Sci. 2017 Nov 1;13(11):1387–97.
Oemiati R. Prevalensi Tumor dan Beberapa Faktor yang Mempengaruhinya di Indonesia. Buletin Penelitian Kesehatan. 2011;39(4), 190–204.
Azhar Y, Agustina H, Abdurahman M, Achmad D. Breast Cancer in West Java: Where Do We Stand and Go? Indonesian Journal of Cancer. 2020 Sep 30;14(3):91–6.
Instalasi Pengendali Data Beban, Kanker dan Jejaring Kanker Nasional. Profil Kanker Timja Payudara RS Kanker Dharmais. 2020; 11-14.
Sinaga ES, Ahmad RA, Shivalli S, Hutajulu SH. Age at diagnosis predicted survival outcome of female patients with breast cancer at a tertiary hospital in Yogyakarta, Indonesia. Pan African Medical Journal. 2018 Nov 7;31(163).
Yohana. The Survival of Breast Cancer Patients in Ibnu Sina Hospital, Makassar. 2016 Azhar Y, Agustina H, Abdurahman M, Achmad D. Breast Cancer in West Java: Where Do We Stand and Go? Indonesian Journal of Cancer. 2020 Sep 30;14(3):91–6.
Allemani C, Matsuda T, Di Carlo V, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018 Mar 17;391(10125):1023-75.
Hutahaean A, Qodir N, Fadilah M, et al. The Description of Hormonal Risk Factors of Breast Cancer Patients in RSUP Dr. Mohammad Hoesin Palembang. E-Jurnal Medika Udayana. 2021 Aug 31;10(8):39–45.
Dong G, Wang D, Liang X, et al. Factors related to survival rates for breast cancer patients. Int J Clin Exp Med. 2014 Oct 15;7(10):3719-24.
Schonberg MA, Marcantonio ER, Li D, et al. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. J Clin Oncol. 2010 Apr 20;28(12):2038-45.
Maishman T, Cutress RI, Hernandez A, et al. Local Recurrence and Breast Oncological Surgery in Young Women With Breast Cancer: The POSH Observational Cohort Study. Ann Surg. 2017 Jul;266(1):165-172.
Thompson AM, Moulder-Thompson SL. Neoadjuvant treatment of breast cancer. Ann Oncol. 2012 Sep;23 Suppl 10(Suppl 10):x231-6.
Takahashi R, Toh U, Iwakuma N, et al. Treatment outcome in patients with stage III breast cancer treated with neoadjuvant chemotherapy. Exp Ther Med. 2013 Nov;6(5):1089-1095.
Fisher S, Gao H, Yasui Y, et al. Survival in stage I-III breast cancer patients by surgical treatment in a publicly funded health care system. Ann Oncol. 2015 Jun;26(6):1161-1169.
Bahk J, Jang SM, Jung-Choi K. Increased breast cancer mortality only in the lower education group: age-period-cohort effect in breast cancer mortality by educational level in South Korea, 1983-2012. Int J Equity Health. 2017 Mar 31;16(1):56.
Robert SA, Strombom I, Trentham-Dietz A, et al. Socioeconomic risk factors for breast cancer: Distinguishing individual- and community-level effects. Epidemiology. 2004 Jul;15(4):442–50.
Fagerholm R, Faltinova M, Aaltonen K, et al. Family history influences the tumor characteristics and prognosis of breast cancers developing during postmenopausal hormone therapy. Fam Cancer. 2018 Jul;17(3):321-331.
Martínez ME, Unkart JT, Tao L, et al. Prognostic significance of marital status in breast cancer survival: A population-based study. PLoS ONE. 2017 May 1;12(5)
Saxena N, Hartman M, Bhoo-Pathy N, et al. Breast cancer in South East Asia: comparison of presentation and outcome between a middle income and a high income country. World J Surg. 2012 Dec;36(12):2838-46.
Walters S, Maringe C, Butler J, et al. Breast cancer survival and stage at diagnosis in Australia, Canada, Denmark, Norway, Sweden and the UK, 2000-2007: a population-based study. Br J Cancer. 2013 Mar 19;108(5):1195-208.
Abdul Rahim SSS, Hayati F, Azhar ZI. Three-year Survival of Women with Breast Cancer in Basrah, Iraq. Oman Med J. 2021 Nov 30;36(6):e327.
Chitapanarux I, Sripan P, Somwangprasert A, et al. Stage-Specific Survival Rate of Breast Cancer Patients in Northern Thailand in Accordance with Two Different Staging Systems. Asian Pac J Cancer Prev. 2019 Sep 1;20(9):2699-2706.
Anders CK, Johnson R, Litton J, et al. Breast cancer before age 40 years. Semin Oncol. 2009 Jun;36(3):237-49.
El Chediak A, Alameddine RS, Hakim A, et al. Younger age is an independent predictor of worse prognosis among Lebanese nonmetastatic breast cancer patients: analysis of a prospective cohort. Breast Cancer (Dove Med Press). 2017 Jun 10;9:407-414.
Atashgar K. A Survival Analysis of Invasive Breast Cancer Patients with and Without in Situ Neoplasm. International Journal of Systems Science and Applied Mathematics. 2018;3(2):30.
Reyngold M, Winter KA, Regine WF, et al. Marital Status and Overall Survival in Patients with Resectable Pancreatic Cancer: Results of an Ancillary Analysis of NRG Oncology/RTOG 9704. Oncologist. 2020 Mar;25(3):e477-e483.
Hinyard L, Wirth LS, Clancy JM, Schwartz T. The effect of marital status on breast cancer-related outcomes in women under 65: A SEER database analysis. Breast. 2017 Apr;32:13-17.
Mursyidah NI, Ashariati A, Kusumastuti E, Rahniayu A. Comparison of Breast Cancer 3-years Survival Rate Based on the Pathological Stages. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga. 2019 Jan 30;10(1):38–43.
Rossi L, Stevens D, Pierga JY, et al. Impact of Adjuvant Chemotherapy on Breast Cancer Survival: A Real-World Population. PLoS ONE. 2015 Jul 27;10(7).
Mathew J, Lee S, Syed BM, et al. A study of ductal versus non-ductal invasive breast carcinomas in older women: long-term clinical outcome and comparison with their younger counterparts. Breast Cancer Res Treat. 2014 Oct;147(3):671-4.
Li CI, Moe RE, Daling JR. Risk of Mortality by Histologic Type of Breast Cancer Among Women Aged 50 to 79 Years. Arch Intern Med. 2003;163(18):2149–2153.
Ntekim AI, Folasire AM, Ali-Gombe M. Survival pattern of rare histological types of breast cancer in a Nigerian institution. Pan Afr Med J. 2019 Oct 29;34:114.
Xuan Q, Gao K, Song Y, et al. Adherence to Needed Adjuvant Therapy Could Decrease Recurrence Rates for Rural Patients With Early Breast Cancer. Clin Breast Cancer. 2016 Dec;16(6):e165-e173.
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